Organomegaly

  • DDx: Hepatomegaly

    • Chronic: alcoholic liver disease, non-alcoholic steatohepatitis, right heart failure.
    • Inflammatory: viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis.
    • Cancer: primary or secondary liver cancer, lymphoma, leukaemia.
    • Myeloproliferative: myelofibrosis, polycythaemia.

  • DDx: Splenomegaly

    • Cancer: lymphoma, CML, liver mets.
    • Portal hypertension.
    • Inflammatory: infectious mononucleosis, endocarditis, malaria, leishmaniasis, brucellosis, TB, hepatitides, RA, SLE.
    • Myeloproliferative: myelofibrosis, polycythaemia.
    • Haemolytic anaemia.
    • Gaucher's disease: autosomal recessive lysosomal storage disease.

  • DDx: Hepatosplenomegaly

    Hepatobiliary:

    • Cirrhosis and portal hypertension.

    Infection:

    • Viral hepatitis.
    • Infectious mononucleosis.
    • CMV
    • Brucellosis
    • Malaria

    Haematological:

    • With lymphadenopathy = lymphoma.
    • Without lymphadenopathy = myeloproliferative disease: polycythaemia vera, essential thrombocytosis, myelofibrosis, chronic myeloid leukaemia.
    • Anaemia: sickle cell anaemia, thalassaemia, pernicious anaemia.

    Others:

    • Amyloidosis
    • Acromegaly
    • SLE
    • Sarcoidosis

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